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Synthesis and antioxidant activity of a new 4-aminocoumarin derivative
dc.contributor.author | Ristić, Novica | |
dc.contributor.author | Radulović, Niko | |
dc.contributor.author | Dekić, Biljana | |
dc.contributor.author | Ristić, Milenko | |
dc.contributor.author | Dekić, Vidoslav | |
dc.date.accessioned | 2023-03-14T11:56:48Z | |
dc.date.available | 2023-03-14T11:56:48Z | |
dc.identifier.citation | Ministry of Education, Science and Technological Development of Serbia [Project No. 172061]. | en_US |
dc.identifier.citation | Ministry of Education, Science and Technological Development of Serbia [Project No. 45022]. | en_US |
dc.identifier.uri | https://platon.pr.ac.rs/handle/123456789/1110 | |
dc.description.abstract | Synthesis, spectral characterization, and evaluation of in vitro antioxidant activity of a new coumarin derivative, 4- ((1,3,4-thiadiazol-2-yl)amino)-3-nitro-2H-chromene-2-one, are described. The synthesis of the new product was performed in three reaction steps, with a good overall yield (78%). The structure was corroborated by detailed spectral analysis, including the 1D and 2D NMR experiments (1H- and 13C NMR; 1H-1H COSY, NOESY, HSQC, and HMBC). The in vitro antioxidant activity was evaluated using the DPPH test. The synthesized compound possesses a good free-radical scavenging activity, IC50=596.7±0.3 μg/ml, and can serve as a model for the synthesis of similar compounds with promising antioxidant effects. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Faculty of Sciences and Mathematics, University of Priština in Kosovska Mitrovica | en_US |
dc.title | Synthesis and antioxidant activity of a new 4-aminocoumarin derivative | en_US |
dc.title.alternative | UNIVERSITY THOUGHT Publication in Natural Sciences | en_US |
dc.type | clanak-u-casopisu | en_US |
dc.description.version | publishedVersion | en_US |
dc.identifier.doi | 10.5937/univtho8-19770 | |
dc.citation.volume | 8 | |
dc.citation.issue | 2 | |
dc.citation.spage | 27 | |
dc.citation.epage | 32 | |
dc.subject.keywords | Coumarin derivative | en_US |
dc.subject.keywords | Spectral characterization | en_US |
dc.subject.keywords | NMR spectroscopy | en_US |
dc.subject.keywords | Antioxidant activity | en_US |
dc.subject.keywords | DPPH | en_US |
dc.type.mCategory | M54 | en_US |
dc.type.mCategory | openAccess | en_US |
dc.type.mCategory | M54 | en_US |
dc.type.mCategory | openAccess | en_US |