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dc.contributor.authorLaban, Bojana
dc.contributor.authorRalević, Uroš
dc.contributor.authorPetrović, Suzana
dc.contributor.authorLeskovac, Andreja
dc.contributor.authorVasić-Anićijević, Dragana
dc.contributor.authorMarković, Mirjana
dc.contributor.authorVasić, Vesna
dc.date.accessioned2023-04-21T07:12:44Z
dc.date.available2023-04-21T07:12:44Z
dc.date.issued2019-12-11
dc.identifier.citationMinistry of Education and Science of the Republic of Serbia (Project No. 172023)en_US
dc.identifier.citationMinistry of Education and Science of the Republic of Serbia (Project No. 172045)en_US
dc.identifier.citationMinistry of Education, Science and Technological Development of the Republic of Serbia (Project No. 172023)en_US
dc.identifier.citationMinistry of Education, Science and Technological Development of the Republic of Serbia (Project No. 172045)en_US
dc.identifier.urihttps://platon.pr.ac.rs/handle/123456789/1244
dc.description.abstractThe simple green method for synthesis of stable L-Methionine (L-Met) capped silver (Ag@LM NPs) and gold (Au@LM NPs) nanoparticles (NPs) without adding any additional reduction agent or stabilizer was developed. Colloidal dispersions were characterized by UV–Vis spectrophotometry. The size and spherical shape of NPs were evaluated by transmission electron microscopy. Their surface covering was confirmed by atomic force microscopy, Fourier transform infrared spectroscopy, dynamic light scattering, and zeta potential measurements. Density functional theory calculations pointed that the preferential adsorption mode of L-Met on both Ag and Au surfaces was a vertical binding geometry via –NH2 group, while horizontal binding mode via eSe and –NH2 groups is also possible. The genotoxicity (evaluated by the micronucleus assay) of NPs, as well as their effects on some oxidative stress parameters (catalase activity, malondialdehyde level), were assessed in vitro using human peripheral blood cells as a model system. The influence of NPs on the morphology of lymphocyte cells studied using atomic force microscopy revealed that the membrane of cells remained unaffected after the treatment with NPs. When considering the effects of NPs on catalase activity and malondialdehyde level, neither particle type promoted oxidative stress. However, the treatment of lymphocytes with Ag@LM NPs induced a concentration dependent enhancement of the micronuclei incidence and suppression of the cell proliferation while Au@LM NPs promoted cell proliferation, with no significant effects on micronuclei formation. The Ag@LM NPs were more prone to induce DNA damage than Au@LM NPs, which makes the latter type more suitable for further studies in nano-medicine.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.titleGreen synthesis and characterization of nontoxic L-methionine capped silver and gold nanoparticlesen_US
dc.title.alternativeJournal of Inorganic Biochemistryen_US
dc.typeclanak-u-casopisuen_US
dc.description.versionpublishedVersionen_US
dc.identifier.doihttps://doi.org/10.1016/j.jinorgbio.2019.110958
dc.citation.volume204
dc.citation.spage110958
dc.subject.keywordsSilveren_US
dc.subject.keywordsGolden_US
dc.subject.keywordsGreenen_US
dc.subject.keywordsNanoparticlesen_US
dc.subject.keywordsL-methionineen_US
dc.subject.keywordsToxicityen_US
dc.type.mCategoryM21en_US
dc.type.mCategoryclosedAccessen_US
dc.type.mCategoryM21en_US
dc.type.mCategoryclosedAccessen_US


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